Xtandi 40 mg Capsule

Xtandi 40 mg Capsule is a drug for the treatment of advanced prostate cancer. Xtandi is used to treat metastatic, castration-resistant prostate cancer that does not respond to surgical or drug therapy to lower testosterone levels.

The main active ingredient of the drug is Enzalutamide 40 mg Capsule, a synthetic non-steroidal anti-androgen that blocks the body’s ability to use any sex hormones.

Principle of operation of Xtandi (Enzalutamide) 40 mg Capsule

Prostate cancer forms in the gland of the male reproductive system, which is located below the bladder and in front of the rectum. The cells of the prostate gland have receptors that bind to androgens – male sex hormones that help these cells grow. In the event of a tumor, its growth is stimulated by the main male sex hormone – testosterone, as well as related hormones.

By reducing the amount of androgens, it is possible to shrink and slow down cancer growth. Xtandi 40 mg is an anti-androgen drug that works by preventing the action of sex hormones, including testosterone, and inhibiting the growth of prostate cancer cells.

Clinical researches

The drug was approved for use in 2012 after a series of clinical trials. The safety and efficacy of Xtandi 40 mg Capsule was evaluated in a study of 1,199 patients with metastatic castration-resistant prostate cancer. According to the results of the studies, the average survival of patients taking the drug was 18.4 months, compared with 13.6 months for those who received placebo. In addition, trials have shown that taking Xtandi 40 mg Capsule reduces the risk of cancer progression by 83% and the likelihood of death by 37%. Enzalutamide 40 mg can significantly delay the initiation of chemotherapy for patients with metastatic prostate cancer from 11 to 28 months.

Mode of application

Xtandi (Enzalutamide 40 mg Capsule) is taken orally in the form of capsules with a daily dosage of 160 mg (four 40 mg capsules). The capsules can be taken with or without food with a full glass of water. If the drug is missed, it is allowed to take the capsule later in the day, but it is not recommended to combine two doses of Xtandi 40 mg Capsule. The dose and schedule for taking Xtandi 40 mg Capsule are determined individually by the attending physician.

Before taking Xtandi (Enzalutamide) 40 mg Capsule

Although the drug is not intended for use by women, it should be borne in mind that Xtandi 40 mg Capsule may cause birth defects in children whose mother or father has taken this medicine. It is recommended to use means to prevent pregnancy during the use of the drug and within 3 months after the end of treatment.

Xtandi 40 mg Capsule may increase the risk of seizures. To make sure this medicine is safe for you, tell your doctor if you have epilepsy, have had a head injury, stroke or brain tumor in the past 12 months, or have seizures.

Interaction with other drugs

Before starting Xtandi 40 mg Capsule treatment, tell your doctor about any other medicines you are taking (including over-the-counter medicines, vitamins, herbal medicines, etc.).

Xtandi should be used with caution if you are taking medications that increase the risk of seizures, as well as antibiotics, antidepressants, bronchodilators, birth control or hormonal pills, insulin or diabetes pills, steroids, or medications for mental illness.

Side effects when taking Xtandi 40 mg Capsule

The most common side effect of Xtandi 40 mg is fatigue (occurs in 30% of patients). Less common (in 10-29% of cases) are side effects such as:

  • back pain, joint and muscle pain
  • diarrhea
  • hot flashes
  • swelling of the hands and feet
  • low white blood cell count
  • headache
  • upper respiratory tract infections
  • dizziness
  • muscle weakness

Fewer than 10% of patients experienced shortness of breath, weight loss, high blood pressure, and dizziness during clinical trials. Xtandi 40 mg Capsule can cause falls and injury from falls.

Xtandi 40 mg Capsule can affect the function of the spinal cord. Stop taking the drug if you experience severe back pain, problems walking, pain or weakness in the lower body, severe numbness or tingling, or loss of bladder or bowel control.

The medicine enzalutamide can cause dizziness and sudden loss of consciousness, so it should be taken with caution when performing high concentration activities.

During therapy

When undergoing a course of Xtandi 40 mg therapy, it is recommended to observe the following recommendations:

  • drink at least 2-3 liters of liquid every 24 hours;
  • for hot flashes, wear light clothing, stay in a cool place and apply cold bandages to your head;
  • avoid contact sports and injury to the skin;
  • minimize or eliminate alcoholic beverages;
  • to devote sufficient time to rest;
  • adhere to proper nutrition;
  • wash your hands often;
  • maintain a normal level of physical activity.

Where to buy Xtandi (Enzalutamide) 40 mg Capsule Online?

The medicine is prescribed strictly according to the prescription of the attending oncologist. It is impossible to buy Xtandi in USA, UK, Mexico, or in any part of the former USSR – the drug is a new development and did not have time to go through the process of approval and registration for sales in Russia.

The oncologist has the right to prescribe the drug Xtandi, provided that in the area of ​​his license to operate this drug is approved for sale, and the oncologist has experience in using it.

Application of Xtandi 40 mg Capsule for the treatment of other forms of cancer The main area of ​​application of the drug Xtandi (enzalutamide) is the treatment of metastatic, castration-resistant prostate cancer.

Are there analogues and substitutes for Xtandi An alternative to Xtandi 40 mg are preparations based on bicalutamide, flutamide and other substances from the group of synthetic non-steroidal anti-androgens, which are also produced abroad. The choice among these drugs can only be professionally made by your attending oncologist.

Xtandi 40 mg Capsule instructions for use

Xtandi 40 mg application instructions are available in English for download on the developer’s official website.